Born 1st Jan. 1988, Taian city, Shandong province, China
Institute of Genetics and Developmental Biology, CAS
Datun Road, Chaoyang District, Beijing, 100101, China
For biology, my interest is in elucidating the mechanisms of the development of a life body to finally construct a model to simulate and predict ontogenesis.
Besides, I am crazy about computational technologies and mining big data. For all the time, I want to dig into amounts of data to help constructing intelligent life.
2009-2012 Exploring the function of protein internal repeats
This is my first scientific project, focusing on protein internal repeats searching, classification and function prediction. Three years’ exploring strengthened my programming skills and the ability of applying bioinformatics tools, laid a solid foundation for future researches. I developed a Makefile based scripts management system and analysis pipeline, and latex based document auto-generation system.
2012-2015 Genome-wide profiling of 5hmC in pluripotency stem cells and MEF
I found 5hmC distribution preferred different cis-regulatory elements in embryonic stem cells and MEF, positively correlated with H3K36me3 profile and designed experiments to verify the regulatory relationship between H3K36me3 and 5hmC. I learned not only the principles of next generation sequencing and related bioinformatics analysis, but also a clear understanding and planning of research.
2012-2015 Transcriptome-wide distribution of m6A in pluripotency and neural stem cells and somatic cells
I for the first time characterized the cell type specific and common m6A modification in cells with different pluripotency, found some new features of m6A distribution, predicted and verified that miRNAs can direct the m6A generation using a sequence-dependent manner for the first time. I formed my own research approaches, learned a lot in overall planning and navigating a project, coordinating cooperation, manuscript writing, submitting and negotiating.
2009-2015 Exploring the way for a meaningful life
This is not a biological research project but a thinking of myself and my life. Five years of research makes me think about myself, know myself, discover myself and find my interests.
|2009-2015||Ph.D.||Bioinformatics||Institute of Genetics and
|2005-2009||Bachelor||Life Sciences||Northeast Forestry University|
Chen Tong*, Hao Ya-Juan*, Zhang Ying*, Li Miao-Miao*, Wang Meng, Han Weifang, Wu Yongsheng, Lv Ying, Hao Jie, Wang Libin, Li Ang, Yang Ying, Jin Kang-Xuan, Zhao Xu, Li Yuhuan, Ping Xiao-Li, Lai Wei-Yi, Wu Li-Gang, Jiang Guibin, Wang Hai-Lin, Sang Lisi, Wang Xiu-Jie, Yang Yun-Gui, and Zhou Qi. (2015) m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell 16, 289–301 (cover story)
Cui Yi*, Xiao Zhifeng*, Chen Tong*, Wei Jianshu, Chen Lei, Liu Lijun, Chen Bing, Wang Xiujie, Li Xiaoran, and Dai Jianwu. (2014) The miR-7 identified from collagen biomaterial based 3-D cultured cells regulates neural stem cell differentiation. Stem Cells and Development 23, 4: 393-405. (* co-first author)
Wu Hua-Jun*, Ma Ying-Ke*, Chen Tong, Wang Meng and Wang Xiu-Jie. (2012) PsRobot: a web-based plant small RNA meta-analysis toolbox. Nucleic Acids Research 40:W22-W28.